I have been kind of busy these days. But there is always some time to play with graphics. Today's molecule is ATP. It's the body's immediate energy source. It works as a cofactor in many enzymes of different kinds. It is also a building block of RNA.
The active part is a double phosphoric acid anhydride. This is an instable "high energy" bond. The hydrolisation to ADP and phosphate has a biological standard free energy of -35 kJ/mol. It is used coupled with endergonic reactions. You can compare the reaction to the hydrolisation of P4O10.
Besides the two energetic bonds you have ribose and adenine forming a "handle".
In physiological conditions ATP can form a complex with Mg2+. This stabilises the negative charges on the oxygen atoms.
The structures were calculated in ArgusLab using the Universal Force Field method. The images were drawn in PyMOL with the ray function.
 Don't call it P2O5 unless glucose is H2CO for you.
Macrocycles, flexibility and biological activity: A tortuous pairing - Here's an interesting paper from the Jacobson, Wells and Walsh labs at UCSF and Stanford that seeks to demonstrate how restricting the flexibility of macr...
5 days ago