I wrote about quinine a
while ago. I was told that I had the structure wrong. This is what it should look like.
The difference is the configuration at the stereogenic quinuclidine carbon.
An important difference to the "epi-quinidine" which I drew before is that a hydrogen bond is not possible. In the picture below it can be seen that the -OH and N are bent away from each other.
Rotation around the σ-bond that would lead to an H-bond is not possible for steric reasons.
This is apparent in the spacefill model.
I used the typical programs (I wrote about before) and the
Open Babel package that I recently read about at
Noel's blog. It's a convient way for converting chemical file types. It was very useful for passing structures between the different modelling and graphics programs.
The difference is the configuration at the stereogenic quinuclidine carbon.
An important difference to the "epi-quinidine" which I drew before is that a hydrogen bond is not possible. In the picture below it can be seen that the -OH and N are bent away from each other.
Rotation around the σ-bond that would lead to an H-bond is not possible for steric reasons.
This is apparent in the spacefill model.
I used the typical programs (I wrote about before) and the Open Babel package that I recently read about at Noel's blog. It's a convient way for converting chemical file types. It was very useful for passing structures between the different modelling and graphics programs.
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